ENTEROVIRAL INFECTION AND ITS RELATIONSHIP WITH NEURODEGENERATIVE DISEASES

Abstract

Neurodegenerative diseases (NDDs) are becoming increasingly
common. They are associated with protein metabolism and structural changes,
which lead to the death of neuronal cells. Viral infections affect these cellular
processes and can become an eatiological factor in neurological diseases.
Enteroviruses (EV) often infect the central nervous system (CNS). Inflammation,
disruption of the host autophagy machinery, and deregulation and protein
accumulation/misfolding are the major changes observed following EV infection.
We therefore discuss the most recent findings on this issue, exploring the possible
role of EVs in the development of NDD.