UNRAVELING THE GENETIC ASPECTS OF PARKINSONISM PLUS: INSIGHTS INTO DISEASE PATHOGENESIS AND POTENTIAL THERAPEUTIC TARGETS

Abstract

Parkinsonism Plus (PP) encompasses a diverse group of neurodegenerative
disorders characterized by parkinsonian symptoms, such as bradykinesia, rigidity,
and tremor, along with additional atypical features. While the etiology of PP
remains elusive, recent advances in genetic research have shed light on its
underlying mechanisms. This review article provides an overview of the genetic
aspects associated with PP, exploring the genes implicated in different subtypes,
their contributions to disease pathogenesis, and the potential therapeutic targets
that have emerged from these findings. Understanding the genetic basis of PP
holds promise for the development of targeted therapies and personalized medicine
approaches