GLANZMANN’S THROMBASTHENIA – A CASE REPORT

Abstract

Glanzmann thrombasthenia (GT) is an autosomal recessive disorder of
platelet aggregation caused by quantitative or qualitative defects in integrins αIIb
and β3. These integrins are encoded by the ITGA2B and ITGB3 genes and form
platelet glycoprotein (GP)IIb/IIIa, which acts as the principal platelet receptor for
fibrinogen . Symptoms include purpura, petechiae, bruising, gingival bleeding,
epistaxis, and menorrhagia. Platelet transfusion is considered the standard therapy
for securing hemostasis. A known case of Glanzmann’s thrombasthenia is presented
with menorrhagia. After failed medical treatment, she was successfully operated for
transabdominal hysterectomy as a last resort