FEATURES OF CELLULAR IMMUNITY IN CHILDREN WITH NEPHROTIC SYNDROME IN THE ARAL REGION

Abstract

In order to study the features of cellular immunity in children with nephrotic
syndrome in the Aral Sea region, we observed 95 children aged 7 to 11 years suffering from NS
(nephrotic form of CGN). Of these: 35 - NS without LD - group 1; 35-NS with LD - 2-group; 25-
LD-3-group. The control group consisted of 25 practically healthy children of the same age. It was
found that in children living in the Aral Sea region with a combined course of nephrotic syndrome
with secondary immunological deficiency, including lymphatic diathesis, there is an increase in
clinical and laboratory symptoms, such as: oliguria (93.7%), widespread edema (85.7 %), fatigue
(74.9%), “chalky” pallor of the skin (70.8%), ascites (64.8%), decreased appetite (44.0%), positive
effleurage symptom (34.5%) , hepatomegaly (29.4%). In the Aral Sea region, with the combined
course of nephrotic syndrome with lymphatic diathesis, cellular immunity is characterized by a
decrease in T-lymphocytes, T-suppressors, T-helpers, PhAN; an increase in B-lymphocytes, ABL
of the kidneys, ABL of the lungs and CIC concentration, which lead to increased manifestation of
clinical symptoms of lymphatic diathesis and can serve as a criterion for early immunodiagnosis
of the risk of complications in such patients