INFLUENCE OF INTERLEUKIN-17 ON SPINAL REMODELING IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS

Abstract

The article presents data from our own studies devoted to studying the level of the pro-inflammatory cytokine - interleukin-17 in patients with axial spondyloarthritis. The level of interleukin-17 was studied in two groups: in patients with spinal ankylosis and in patients without spinal ankylosis , as well as in healthy individuals. The level of interleukin-17 was also compared with clinical and functional signs of the disease. According to the research results, an increase in the level of interleukin-17 was revealed by 10.5 times compared to healthy individuals and by 1.8 times in patients with no signs of ankylosis. An increase in the level of interleukin-17 shows a high correlation with spinal damage and clinical and functional signs of the disease, which once again proves its pathogenetic significance in the development of ankylosis.