VALERIAN ROOT IN THE TREATMENT OF SLEEP PROBLEMS AND RELATED DISORDERS - A SYSTEMATIC REVIEW AND METAANALYSIS

Abstract

Annotation
Sleep problems are widespread and associated with a variety of comorbidities, including anxiety. Valerian (Valeriana officinalis) L.) is a popular herbal remedy used as a sleep aid, but results from previous clinical studies are inconsistent. This study was conducted to update and re-evaluate the available evidence to understand the reason for the conflicting results and to provide a broader understanding of the use of valerian in co-occurring disorders. PubMed, ScienceDirect and the Cochrane Library were searched for publications regarding the effectiveness of valerian in the treatment of sleep problems and related disorders. A total of 60 studies were included in this review (n=6894), and a metaanalysis was conducted to evaluate the effectiveness of improving subjective sleep quality (10 studies, n=1065) and reducing anxiety (8 studies, n=535). ). The results indicated that the conflicting  results may have been due to variable quality of the plant extracts and that more reliable effects could be expected from the  whole root/rhizome. Additionally, therapeutic benefits can be optimized when combined with appropriate herbal partners. There were no serious adverse events associated with valerian use in patients aged 7 to 80 years. In conclusion, valerian may be a safe and effective remedy for improving sleep and preventing sleep-related disorders. However, due to the presence of multiple active  ingredients and the relatively unstable nature of some active ingredients, quality control processes, including standardization methods and expiration dates, may need to be reviewed. therapeutic benefits can be optimized when combined with appropriate herbal partners. There were no serious adverse events associated with valerian use in patients aged 7 to 80 years. In conclusion,  valerian may be a safe and effective remedy for improving sleep and preventing sleep-related disorders. However, due to the  presence of multiple active ingredients and the relatively unstable nature of some active ingredients, quality control processes,  including standardization methods and expiration dates, may need to be reviewed. therapeutic benefits can be optimized when combined with appropriate herbal partners. There were no serious adverse events associated with valerian use in patients aged 7  to 80 years. In conclusion, valerian may be a safe and effective remedy for improving sleep and preventing sleep-related disorders. However, due to the presence of multiple active ingredients and the relatively unstable nature of some active  ingredients, quality control processes, including standardization methods and expiration dates, may need to be reviewed. Valerian may be a safe and effective remedy for improving sleep and preventing sleep-related disorders. However, due to the presence of multiple active ingredients and the relatively unstable nature of some active ingredients, quality control processes, including  standardization methods and expiration dates, may need to be reviewed. Valerian may be a safe and effective remedy for  improving sleep and preventing sleep-related disorders. However, due to the presence of multiple active ingredients and the relatively unstable nature of some active ingredients, quality control processes, including standardization methods and expiration  dates, may need to be reviewed.