SYSTEMATIC REVIEW: THE ROLE OF KINESINS IN PARKINSON’S DISEASE
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Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the substantia nigra and the
accumulation of alpha-synuclein aggregates. The transport of essential cellular
components, including organelles, proteins, and vesicles, is crucial for neuronal
function and survival. Kinesins, a family of microtubule-associated motor proteins,
play a critical role in intracellular transport. This systematic review aims to
consolidate current evidence regarding the involvement of kinesins in the
pathophysiology of PD and their potential as therapeutic targets.